Medicinal chemistry [MCHIB108]

Learning outcomes

The student will develop and master the following skills • restitution of theoretical concepts of chemistry ; • qualitative and quantitative description of the material ; • representation of (bio)molecules in the plane and in space ; • solving quantitative problems ; • interpretation and construction of graphs In particular, at the end of the course, the student will be able to : • describe the microscopic structure of matter (atomic and molecular level); • master the nomenclature and recognition of functional groups in inorganic and organic chemistry; • predict the properties of molecular (bio)chemical building blocks (geometry, polarity, aromaticity, conformation, stereochemistry, configurations and chirality) • to use the theory of perfect gases in relation to medical problems; • define the properties of the solutions (concentration, cryoscopic lowering, conductivity, pH, etc.); • describe and weight reaction equations (dissociation, acid-base, redox, precipitation, complexation, combustion, etc.); • perform stoichiometry calculations • describe the dynamic equilibrium state and its displacement and reason about the equilibrium constants; • to predict, with the help of thermodynamic concepts, the evolution of (bio)chemical processes; • use the concepts of kinetics to describe the rate of enzymatic reactions; • describe the major classes of biochemical reactions and the underlying molecular mechanisms; • describe the principles of characterisation techniques and (bio)spectroscopies

Objectives

The main objectives of this course are to: • to provide the student with a rigorous basic training in chemistry related to medical issues; • describe matter (pure bodies or mixtures) in the three levels of knowledge (macroscopic, microscopic and symbolic) • describe (bio)chemical molecules and infer properties ; • explain and predict (bio)chemical transformations on the basis of thermochemical and kinetic concepts and the analysis of functional group transformations • solve problems using mathematical reasoning and tools; • interpret data presented in different forms (table, graph, text, etc.)

Content

The course develops the theories of chemistry relevant to medical and biochemical applications. The description of the atom and the nature of chemical bonding justify the structure and geometry of (bio)molecules, their functional groups and states of matter. The conformational analysis of simple organic molecules provides an understanding of the basis of molecular dynamics. This molecular description explains the pharmacological activity of natural compounds and/or drugs. Thermochemistry and kinetics allow a critical and quantitative description of (bio)chemical processes. The analysis of enzymatic transformations of functional groups of biomolecules allows a comparison of the major classes of reactions in biochemistry. Examples related to the medical field illustrate the chemical concepts.