Post irradiation mechanisms in cells [SPHYM140]

Objectives

Understand interactions between ionizing radiation and living cells

Content

- Chapter I: Radiation-matter interaction
o Stopping power, attenuation coefficient, fragmentation of heavy ions
o From macroscopic dosimetry to microdosimetry
o Radiochemistry

- Chapter II: Fundamental radiobiology
o DNA: Damage generation, chromosomal rearrangements and DNA repair
o Cell death and survival (biological understanding and mathematical model)
o Radiobiological quantities (LET, RBE, OER, ...)
o Non-targeted effects

- Chapter III: What about the clinic?
o Introduction to radiotherapy
o The 5 R's of radiobiology
o Fractionation, a key element of radiobiology
o Radiotherapy treatment sequence

- Chapter IV: How to modify the cellular response to radiation?
o By influencing the physical phase (dose deposition, dose rate, etc.)
o By modifying the chemical phase
o By modifying the biological phase (Repair, Repopulation, Redistribution, Radiosensitivity)

- Chapter V: Space radiation biology
o Introduction to space radiation sources
o Space exploration and large LET particles
o Radioprotection of astronauts