Course 2024-2025

Molecular mechanisms of neurological diseases [SMEDM137]

  • 3 credits
  • 22h
  • 1st quarter
Language of instruction: French / Français

Learning outcomes

The chapters in this course focus on the basic molecular and cellular mechanisms of the most common neurodegenerative diseases (Alzheimer's, ALS, IBS, Parkinson's, lysosomal or mitochondrial diseases, demyelinating diseases), rather than on their clinical/diagnostic/therapeutic presentations. The first two courses will provide the neuroanatomical and cellular basis for understanding the CNS and the main pathophysiological mechanisms related to neurodegeneration (protein aggregation, protein dissemination, neuroinflammation, oxidative stress, mitochondrial or lysosomal defects, axo-plasmic transport, excitotoxicity, ...). These mechanisms will be put into the context of selected neurodegenerative diseases. The mechanistic specificities of each disease as well as elements of genetics will be integrated into the teaching. I hope that this teaching will be complementary to the optional course SBIOM210 offered in MA2 BBMC.

Objectives

To understand the pathophysiology of certain neurological and neurodegenerative diseases, focusing on the mechanisms and molecular aspects known to date and their experimental approaches.

Content

Introduction to Neuroanatomy Basics of Neuropathology Alzheimer's disease Parkinson's disease Amyotrophic lateral sclerosis Spinal cord injury Multiple sclerosis and other demyelinating diseases

Table of contents

Introduction to neuroanatomy Notions of neuropathology Alzheimer's disease Parkinson's disease Huntington's disease Amyotrophic Lateral Sclerosis Spinal cord injuries Multiple sclerosis and other demyelinating diseases

Exercises description

None


Teaching methods

Ex-cathedra lecture, external lecturers expert in each field/neurodegenerative pathology. Active participation of students through oral presentation of scientific publications.

Evaluations

The examination consists of an oral presentation of an original scientific article and a written paper summarising the main results of the study and the perspectives proposed by the student.

Language of instruction

French / Français

Location for course

NAMUR

Organizer

Faculté des sciences
Rue de Bruxelles, 61
5000 NAMUR

Degree of Reference

Master's Degree