Strategy for the Synthesis of Complex Molecules [SCHIM214]

Learning outcomes

Importance of strategic and tactical decisions in multistep synthesis

Strategically important transformations

Types of synthesis strategy

Tactically important reactions and their application

Objectives

Allow the students to come to grips with the most common strategic decisions taken in complex molecule synthesis, and to implement syntheses using appropriate tactical choices.

Content

The history of complex molecule synthesis, retrosynthesis, as well as the concepts of strategy and tactics are introduced.

Each strategic concept is illustrated by one or several examples of multistep syntheses.

Table of contents

1. Introduction
2. Ring-forming Reactions
3. Symmetry-based Strategies
4. Latent Functionality
5. Tethering
6. Tandem and Domino Processes
7. Multicomponent Reactions
8. Iterative Reactions and Bidirectional Synthesis
9. Parallel and Combinatorial Synthesis
10. Supramolecular Control
11. Biological Methods
12. Biomimetic Synthesis

Exercises description

Des exercices facultatifs sont disponibles en ligne.