Course 2024-2025

Organometallic Synthesis and Catalysis [SCHIM114]

  • 4 credits
  • 12h
  • 2nd quarter
Language of instruction: English

Learning outcomes

Electronic structure and geometry of transition metal complexes

Structure-reactivity relationships in transition metal complexes

Reactivity of polar organometallics

Catalytic cycles involving transition metal complexes

Hydrogenation reactions

Cross-coupling reactions

CH activation reactions

Objectives

The lecture is designed to give a first overview of the reactivity of transition metal complexes and their uses as catalysts.

A rational approach based on structure and reaction mechanisms is used.

 

Content

The main families of transformations employing organometallics are reviewed and a structural and mechanistic approach is applied.

Table of contents

CHAPTER 1 : Polar organometallic reagents

CHAPTER 2 : Hydrometalation and carbometallation

CHAPTER 3 : Transition metal complexes

CHAPTER 4 : Cross-coupling reactions

CHAPTER 5 : Hydrogenations reactions

CHAPTER 6 : Alkenes metathesis

CHAPTER 7 : C-H activation reactions


 

Exercises description

Some exercises will be done during the lessons


Teaching methods

Traditional lecture in English. Student interactivity is encouraged.

Evaluations

A written examination of 2-3 hours based on recent publications that are handed out beforehand.

Recommended readings

Course notes are provided in PDF format.

Additional reading:
Specialised books
R. H. Crabtree « The Organometallic Chemistry of the Transition Metals »
J. Tsuji « Transition Metal Reagents and Catalysts: Innovations in Organic Synthesis » ; « Palladium Reagents and Catalysts: Innovations in Organic Synthesis » ; « Palladium Reagents and Catalysts: New Perspectives for the 21st Century » ; « Palladium in Organic Synthesis »
M. Schlosser « Organometallics in Synthesis : A Manual »
L. S. Hegedus « Transition Metals in the Synthesis of Complex Organic Molecules »
Oxford Chemistry Primers:
P. R. Jenkins « Organometallic Reagents in Synthesis »
M. Bochmann « Organometallics 1 » ; Organometallics 2 »
N. N. Greenwood, A. Earnshaw « Chemistry of the Elements »
F. A. Cotton, G. Wilkinson « Advanced Inorganic Chemistry »
General books
J. Clayden, N. Greeves, S. Warren, P. D. Wothers « Organic Chemistry »
K. C. Nicolaou, E. J. Sorensen « Classics in Total Synthesis »
K. C. Nicolaou, S. A. Snyder « Classics in Total Synthesis II »
L. Kürti, B. Czakó « Strategic Applications of Named Reactions in Organic Synthesis »

Handbook of Functionalized Organometallics: Applications in Synthesis. Editor(s):. Prof. Paul Knochel

Organotransition Metal Chemistry: From Bonding to Catalysis  : John Hartwig

Language of instruction

English

Location for course

NAMUR

Organizer

Faculté des sciences
Rue de Bruxelles, 61
5000 NAMUR

Degree of Reference

Master's Degree