Normal and pathological ageing [SBIOM125]

Learning outcomes

• identify the challenges of the ageing of the population
• understand the challenges of this ageing in terms of research and clinical management
• know the different models for studying ageing
• know the different signaling pathways mainly involved in the ageing process (DNA damage, IGF-1, mTOR, etc.)
• understand the dysfunctions associated with age (neurodegenerative diseases, progeroid diseases, sarcopenia, frailty, etc.)
• understand the involvement of cellular senescence in normal and pathological ageing

Objectives

The objective of is to understand the biological mechanisms involved in the ageing process through the description of research carried out on cell culture, model organisms and human population. The aim is also to understand the diseases associated with dysfunction of these mechanisms such as progeroid diseases, neurodegenerative diseases, sarcopenia and frailty. We will present the socio-economic issues of the ageing of the population and the challenges in terms of research and clinical management.

Content

• Introduction and presentation of demographic and socio-economic data
• Clinical impact: meeting with a geriatrician, presentation of the frailty syndrome
• Current models for the study of ageing: cell models, model organisms and research on humans (longitudinal studies, presentation of European projects, etc.)
• Signaling pathways mainly involved in aging (DNA damage, IGF-1, mTOR, etc.)
• Diseases related to age-related dysfunctions such as progeroid diseases, neurodegenerative diseases, sarcopenia and frailty