Learning outcomes
Students will be able:
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to design an experimental study to identify therapeutic targets
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to identify lead compounds
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to characterize pharmacokinetic (PK) and pharmacodynamic (PD) properties of lead compounds
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to assess in vitro and in vivo toxicity of lead compounds
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to apply critical thinking and analytical skills to interpret data sets
Objectives
This course provides a comprehensive overview of preclinical drug development process. Each stage of the process is developed in-depth and presented according to the current EMA (European Medicines Agency) legislation.
Content
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General Introduction: Drug Business- concepts & metrics
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Identification of Drug Targets
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Drug Discovery
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Preclinical Drug Development
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Pharmacokinetics
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Pharmacodynamics
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In vitro toxicology
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In vivo toxicology
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Reproductive and developmental toxicity
Exercises description
Practicals
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Cell Miner / Connectivity Map : Data Mining
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Genotoxicity Assay : Ames Test
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Cytotoxicity Assay : MTT
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Hepatotoxicity Assay : Steatosis measurement
Teaching methods
Lectures combined with 30 hrs practicals.
Evaluations
Oral exam: /16
Practicals: reports are graded /4
The exact modalities of the evaluation are likely to be modified during the preparation of the examination schedules, depending on the practical constraints with which the faculty administration may be confronted, or in the event of illness / force majeure / encroachment with an internship, or because of the health situation related to the coronavirus.
Recommended readings
PowerPoint presentations, textbook of practicals, research and review articles.
Language of instruction
English
Location for course
NAMUR
Organizer
Faculté de médecine
rue de Bruxelles
61
5000 NAMUR
P. 081724347
F. 081724327
administration-medecine@unamur.be
Degree of Reference
Master's Degree