Clinical biology [MPHAM121]

1) Introduction to clinical biology: Prof François Mullier: 2H

 

2) Introduction to ISO15189: PharmD PhD Emilie Catry: 2h

 

3) Off-site biology : PharmD PhD Emilie Catry : 2h

 

4) Proposed course outline for medical biochemistry Master Pharmacie - UNamur Dr Mélanie Closset 8h

 

1.     Introduction

 

2.     Nature and specificities of biological samples in medical biochemistry  

 

3.     Analytical methods frequently used in biochemistry (reminder)

 

4.     Implementation of a medical biochemistry assay: analytical performance, calibration, internal and external quality control, etc.

 

5.     Clinical applications 

 

Physiopathological background, parameters measured and associated analytical methods in the context of..:

 

a.     Liver functions 

 

b.     Thyroid function

 

c.     Tumour markers

 

d. Protein balance

 

5) Proposed course outline haematology-cytology Master pharmacie Unamur : PhD Chloé Nobis : 2h + PharmD PhD Laetitia Moreno 2h

 

1. Blood

 

1.1. Blood constituents

 

1.2. Plasma and serum

 

1.3. Blood cells

 

 

 

2. Haematopoiesis

 

2.1. Location of haematopoiesis  

 

2.2. Haematopoietic stem cells

 

2.3. Myelopoiesis

 

2.4. Lymphopoiesis

 

 

 

3. Blood studies

 

3.1 Clinical signs

 

3.2 Blood count

 

3.3 Myelogram and bone marrow biopsy

 

 

 

4. Decreased number of normal blood cells

 

4.1. Anemia

 

4.2 Thrombocytopenia

 

4.3. Neutropenia and agranulocytosis   

 

4.4. Pancytopenia

 

4.5. Monocytopenia

 

4.6. Lymphopenia

 

 

 

5. Increase in the number of normal blood cells

 

5.1. Polycythemia

 

5.2. Thrombocytosis

 

5.3. Hyperleukocytosis

 

5.4. Neutrophil Polynucleosis

 

5.4. Hypereosinophilia

 

5.5. Basocytosis

 

5.6. Monocytosis

 

5.7. Lymphocytosis

 

 

 

6. Presence of cells usually absent from the blood

 

6.1. Blastosis

 

6.2. Myeloma

 

6.3. Plasmacytosis

 

6.4. Erythroblastosis

 

 

 

7. Haemogram abnormalities associated with certain physiological or pathological situations

 

7.1. Pregnancy

 

7.2. Cirrhosis

 

7.3 Chronic renal failure

 

7.4. Endocrine insufficiency

 

7.5. Inflammatory syndrome

 

 

 

8. Adenopathy & splenomegaly

 

8.1. Definition and anatomical summary

 

8.2. Benign and malignant causes

 

8.3. Superficial and deep adenopathy

 

6) Microbiology module: Prof Olivier Denis

 

Introduction: 

 

- Importance of infectious diseases in human medicine

 

- Resistance to anti-infectives

 

- One-Health" concept

 

Pre-analytical aspects of microbiology

 

- Collecting a sample

 

- Collection of relevant clinical data

 

- Transporting samples to the laboratory

 

Analytical aspects

 

- Direct examination and antigen detection

 

- Culture in microbiology

 

- Automation of microbial cultures

 

- Identification 

 

- Determination of antibiotic sensitivity

 

Post-analytical aspects

 

- Validation and interpretation of results

 

- Communication of results to the prescriber

 

 

7) Pharmacogenetics-Molecular biology in oncology: principles and applications (2h): PhD Jonathan Degosserie

 

 

 

8) Haemostasis (2h): Prof François Mullier: choice by the students in the introductory course from the following subjects

 

Importance of the pre-analytical phase in haemostasis.Investigation of primary haemostasis.

 

Investigation of plasma coagulation and fibrinolysis.Preoperative work-upThrombophilia assessmentClarification of thrombocytopeniaRational prescription of haemostasis testsMonitoring anticoagulantsMonitoring antiaggregantsSeminar: Type II heparin-induced thrombocytopeniaClinical cases: interpretation of haemostasis testsRole of the haemostasis laboratory in emergency situations

 

9) Immunohematology Ph.Biol. PhD Laetitia Moreno (2h)

 

General introduction to immuno-haematology, test principles and history.Details of the main blood systems: ABO RH phenotype and KELL phenotype.Clinical interest and practical application: immuno-haematology and the blood bank.

 

10) The HLA system: Ph.Biol. Liesbeth Daniels (1h)

 

An introduction and its clinical relevance in solid organ transplantation, haematopoietic stem cell transplantation, HLA-associated diseases, pregnancy and transfusion-related pathology.

 

11) Clinique de l'anémie Patient Blood Management Prof Sarah Lessire (3h)